insoluble

To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins.

It’s a detective drama with no resolution, a morality tale with an insoluble ambiguity at its heart.

In one, antibodies attack a cell-surface protein on neurons called IgLON5, causing abnormal sleep patterns and a buildup of tau, the protein that forms insoluble tangles in the brains of people with Alzheimer’s disease.

"Cellulose is difficult to digest because it is insoluble. Fiber in the gut is like a tree-trunk in a swimming pool, it gets wet, but it does not dissolve."

“It’s just too hard, too complicated, too insoluble.”