vesicle

The findings speak to the value of using universal adult donor cells to create these extracellular vesicle therapies, the researchers said, because they don't carry the risk of generating an immune response.

To unravel this mechanism, they created a computer model of a vesicle containing active cytoskeletal components used for movement.

"That is quite astonishing, as GTPase-dependent vesicle formation was previously thought to be only carried out within eukaryotic cells, between the membrane-bound intracellular compartments. Our finding suggests that components of eukaryotic intracellular vesicle trafficking could have evolved much earlier in evolutionary history than previously assumed."

"Here we show that EVs in salt-loving archaea can transport an RNA cargo and thus help cells communicate with each other. Also, we reveal exciting new insights into the evolutionary development of this communication strategy. Our study provides the basis for further studies into the evolutionary relationships between prokaryotic and eukaryotic vesicle formation and might help solving the puzzle of the evolution of the eukaryotic cell."

They then used fluorescent dyes to inspect the mixtures and judge if vesicle formation had taken place.