granules

He hated that I left granules of detergent all over the washer and garage floor.

The granules, which seem to sort mRNAs so they can later be translated into proteins or degraded, were the main focus of Kedersha’s research career.

The stress granules she discovered are in textbooks.

What the team at Duke-NUS has now discovered is that the release of particulate mast cell granules, which contain these bioactive chemicals, is controlled by two members of an intracellular multiprotein complex called inflammasome.

"We discovered that the inflammasome components played a surprisingly crucial role in transporting particulate mast cell granules which are typically packed in the cell centre to the cell surface where they are released. This surprising discovery gives us a precise target where we can intervene to prevent the cascade of events initiated in mast cells that leads to anaphylactic shock."