malignancy

"This is a very important finding because it provides insights into how blood cells develop, and can help to establish how alterations in Nup358 contribute to blood malignancies."

Ion channels are gateways within cells that tightly control the inward and outward flow of essential ions, such as potassium and calcium, and are thought to be critically linked to cancer malignancy and progression.

"Silencing of the SIX2 gene, on the other hand, significantly reduced the malignancy of cancer cells that are resistant to hormonal therapies," Doctoral Researcher Noora Leppänen of the University of Eastern Finland notes.

The study argues that targeting cell-in-cell events as an approach to treating cancer should be abandoned, as these phenomena are not unique to malignancy.

"Selectively targeting SAS1B has the potential to have broad and profound impact on the treatment, and therefore reduction in mortality, of multiple malignancies," Slingluff and his colleagues write in their new paper.