make callous

They humanize those whom prosperity and comfort might make callous.

He was only a little indifferent to human suffering—having witnessed much of it—and usage will make callous the most sensitive natures.

Here was one who felt grief acutely, rebelliously, and passionately, yet whom sorrow did not sear or harden, suffering did not make self-absorbed or morbid, or pain make callous.

It will give you pain and trouble, or make callous the spot where it rests.