associated with

A new study from Karolinska Institutet in Sweden shows that long-term use of common cardiovascular drugs is associated with lower risk of dementia later in life.

The results show that long-term use of antihypertensive drugs, cholesterol-lowering drugs, diuretics and blood-thinning drugs is associated with between 4 and 25 percent lower risk of dementia.

One possible explanation is that these drugs increase the risk of microbleeds in the brain, which are associated with cognitive decline.

"We found these particular transcription initiating sites in nodules, but not in the roots or any other tissues, suggesting they are for tissue-specific transcription and associated with nodule-specific function," said Ma.

"We have found nearly 7,000 genes that have the alternative transcription initiation within the coding sequences. These alternative transcription initiation sites tend to be tissue-specific and associated with histone modifications," Ma said.