testis

Previous research has shown that STK33 is enriched in the testis and is specifically required for the formation of functional sperm.

Most importantly, mice and men with these mutations have no other defects and even have normal testis size.

"We were pleased to see that the mice did not show signs of toxicity from CDD-2807 treatment, that the compound did not accumulate in the brain, and that the treatment did not alter testis size, similar to the Stk33 knockout mice and the men with the STK33 mutation," Sutton said.

"In humans, differently from other animal species and lower mammalians, testis are located outside of the abdomen. This contributes to the maintenance of an organ temperature 2º to 4° C below core body temperature."

By employing advanced sequencing techniques, the researchers identified significant differences in DNA methylation across thousands of regions in both the brain and testis of the affected frogs.