secretion

With the drug, there was a marked increase in the secretion of the anti-inflammatory signal, confirming their idea that not the number but the function of B cells responds to the treatment, according to the research published online on June 18, 2024, in Neurology® Neuroimmunology & Neuroinflammation, an official journal of the American Academy of Neurology.

Having found that BKCa helps cancer cells with reprogramming their metabolism, Dr. Bischof, first author of the study, specifically looked for evidence of the Warburg effect by measuring lactate concentrations over time; higher levels of lactate secretion imply a shift towards metabolism that does not use oxygen.

As expected, the presence of BKCa not only increased lactate secretion, but also increased the ability of breast cancer cells to grow without oxygen.

In animals, GLP-1 — a hormone that stimulates insulin secretion and inhibits food intake — was shown to greatly impact taste sensitivity to sweetness.

They discovered that disruption of the internal clock in the epithelial cells lining the intestine alters secretion of cytokine proteins, leading to heightened inflammation, increased numbers of immunosuppressive myeloid cells and cancer progression.