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pain
noun as in physical suffering
noun as in mental suffering
Strongest matches
agony, anguish, anxiety, bitterness, grief, heartache, misery, sadness, shock, suffering, torment, woe, worry
Strong matches
affliction, despondency, distress, hurt, malaise, martyrdom, rack, torture, travail, tribulation, wretchedness
noun as in problem
verb as in bother, trouble
Strong matches
ache, afflict, aggrieve, agonize, ail, anguish, annoy, bite, chafe, chasten, constrain, convulse, discomfort, disquiet, distress, exasperate, excruciate, gall, grieve, gripe, harass, harm, harrow, hurt, inflame, injure, irk, irritate, nick, prick, punish, rack, rile, sadden, smart, sting, strain, stress, suffer, throb, tingle, torment, torture, upset, vex, worry, wound
Weak matches
Example Sentences
A research team at the University of Vienna, led by medicinal chemist Markus Muttenthaler, has developed a new class of oral peptide therapeutic leads for treating chronic abdominal pain.
Current medications used to treat chronic abdominal pain often rely on opioids.
Less well-known is that oxytocin can also affect pain perception.
When the peptide hormone oxytocin binds to these receptors, it triggers a signal that reduces pain signals in the gut.
"Our research highlights the therapeutic potential of gut-specific peptides and offers a new, safe alternative to existing pain medications, particularly for those suffering from chronic gut disorders and abdominal pain," explains Muttenthaler.
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From Roget's 21st Century Thesaurus, Third Edition Copyright © 2013 by the Philip Lief Group.
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