hitherto

About a dozen Donald Trump campaign aides spoke to Tim Alberta, a staff writer at The Atlantic, about how their candidate strayed from a hitherto on-message campaign to embark on a series of offensive, threatening and self-defeating verbal adventures that have left his team utterly demoralized heading into Election Day.

He wrote this summer in Current Opinion in Gastroenterology that the syndrome “may not be as rare as thought hitherto.”

Spain’s 16th century conquest of Mexico created a huge and profitable European market for the rich pigment, hitherto unknown on that continent.

Agency scientists are monitoring large databases containing medical information on millions of Americans for patterns that might suggest a hitherto unknown side effect of vaccination, said Dr. Demetre Daskalakis, director of the C.D.C.’s National Center for Immunization and Respiratory Diseases.

"In spite of a series of challenges, a study like this demonstrates how extra effort can reveal important information about hitherto uncharacterized genetic variants and the role they play in a variety of childhood and adult illnesses," said Struan F.A.