extrusion

Dekker provided the first demonstration of this loop extrusion predicted by Mirny, collaborated on synthetic cells with Schwille, and developed new ways to use nanopores—holes or membranes of nanometer size—to sequence DNA and proteins.

Mirny predicted that DNA inside cells is folded up and organized by specialized proteins forming molecular motors, in a process called “loop extrusion.”

The researchers used a technique called adaptive laboratory evolution to create a strain that is resilient to extrusion temperatures.

The answer to stopping asthma symptoms may lie in cell extrusion, a process the researchers discovered that drives most epithelial cell death.

In previous studies, the scientists found that the chemical compound gadolinium can block extrusion.