profound

A three-week inquest found Ms Smith, from Braintree, was not kept safe and staff failures to recognise that she was autistic had a "profound impact" on her care.

She had a "deep bond with the populace", he said, and her passing would "evoke profound national mourning".

Analysts warn the spat between the two mercurial leaders could have a profound impact on security in the hemisphere.

The influential critic Edmund Wilson, who helped establish Hemingway’s literary reputation, perceptively stated “his prose is of the first distinction” and conveys “profound emotions and complex states of mind.”

It is much more profound, many say, than seeing the replica at the National Anthropological Museum in Mexico City.