debilitate

The condition, which causes long-term and often debilitating exhaustion, affects millions of people around the world, including more than 400,000 individuals in the UK.

Much-anticipated medicines failed to deliver on their promise or came with debilitating side effects.

A spokesperson from the mental health charity Mind said anxiety could have a "debilitating" impact and people with the condition could also be suffering multiple health issues.

On a follow-up call from backstage at a later show in Detroit, Hollis recalled a period of debilitating psychosis he experienced at 18 years old.

The party remains in a debilitating rut, refusing to truly challenge the runaway power of corporate capitalism that has caused ever-widening income inequality.