most climacteric

He went on to deplore the blind prejudice of unprofessional persons, who choose to fancy that other diseases creep, but Insanity pounces, on a man; which he expressed thus neatly: "that other deviations from organic conditions of health are the subject of clearly defined though delicate gradations, but that the worst and most climacteric forms of cerebro-psychical disorder are suddenly developed affections presenting no evidence of any antecedent cephalic organic change, and unaccompanied by a premonitory stage, or by incipient symptoms."