downside

“One downside, though: It’s pretty male-dominated.”

"If you’re moving up the timeline of a purchase and there is no downside, it might make sense to buy now. If there is a downside, like getting an outgoing model instead of a new model, or if you might be making a rushed and hasty buying decision, it might make sense to wait. We simply don't know enough about what is going to happen," said Jacob Rheuban, founder and owner of Prevelo Bikes, a U.S.-based company that has navigated tariffs on the bicycles it imports.

Carsley will start work on his report to Tuchel presumably after a rest, and admitted he harbours one major downside from his time in charge.

The downside is that their limited lifespan results in vast numbers of spent LIBs that contain dangerous heavy metals and other hazardous materials.

However, the downside is that a complete blockade of this "editing office" also affects healthy cells, resulting in significant side effects of any spliceosome inhibitor developed so far.