profoundly

“I’m deeply grateful and profoundly moved because I watched my father accept this award in 1981,” Broccoli said.

In rare cases, symptoms of Tay-Sachs and Sandhoff disease appear later in childhood or even in early adulthood, progressing more slowly and offering a longer -- but still profoundly challenging -- life course.

In these early years, access to healthcare, good nutrition, early learning, and a safe environment profoundly shapes a child's future.

There are many within the faith who have experienced this as a deeply painful time and for whom the direction the institution takes now is profoundly important.

But what has changed profoundly in our society — and also explains the shift worldwide — is the explosion of social media and the dramatic shift towards an all-propaganda media diet for so many people.