metastasis

Zarif plans to collaborate with colleagues at Johns Hopkins to launch a clinical trial of JHU083 in patients with treatment-resistant prostate or bladder cancer to see if it shrinks tumors and prevents metastasis.

Administering the nanoparticles systemically improved survival rates and inhibited metastasis across various cancer types.

"This further indicates that the ability of the cells to pull on each other and hold themselves clustered together becomes weaker as the tumor grows, potentially increasing metastasis risk."

"And cell movement underlies embryonic development, drives wound healing and contributes to tumor metastasis," she explained.

"We have identified the novel protein FOXF1 that stabilizes blood vessels inside the lung tumors, decreases intertumoral hypoxia and prevents lung cancer metastases," explained Dr. Kalin, the senior author on this study.