inhibitor

"If this complex is disrupted, it can lead to the death of the affected cell. For this reason, spliceosome inhibitors are considered as potential anti-cancer drugs."

One idea is to locate binding sites on the DNAJB1 protein to which a drug inhibitor could bind.

Abrocitinib is a JAK1 inhibitor drug that works to suppress inflammation, specifically pro-inflammatory chemicals called cytokines that are involved in an overactive immune system.

However, treatment with an enzyme inhibitor that prevents the activation of lipids can restore balance and alleviate symptoms.

"These encouraging results highlight the potential for oncolytic immunotherapy to synergize with immune checkpoint inhibitors, offering a new avenue for patients who have exhausted other treatment options," Li said.