engraft

To address the need for more effective treatment for PKD patients, the NTU research team sought to better understand the disease by engrafting their newly developed mini kidneys into mice.

When applied to the skin of mice -the only animal model able to test engineered bacteria to date- they engraft, live and produce the protein.

For the study, the mice were engrafted with human liver cells and human red blood cells.

However, after tens of thousands transplants, little was known about which donor strains provide long-term engraftment, and which engraft early after the transplant.

Jimi also needed chemotherapy to kill off existing cells in his bone marrow so that his edited stem cells would have room to engraft and grow.