become exhausted

It is now well-appreciated that uncontrolled tumors can indeed be recognized by patients' T cells but have lost their ability to kill the tumor and subsequently become exhausted from their fight.

But during chronic infections, because of the constant need to generate effector cells, naive CD4 T cells are highly solicited and may become exhausted.

“The Russians come at us in waves — we become exhausted, we have to leave our positions. This is repeated many times,” Oleksandr said.

As people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19.

Ohtani isn’t self-destructive like Puig and therefore won’t decline as a player like Puig, but that won’t stop his teammates from resenting him if they become exhausted of speaking on his behalf.