analgesic

Interestingly, menthol also has high medicinal value due to its analgesic, anti-inflammatory, and anti-cancer effects.

"It's thought that acetaminophen exerts its analgesic effect through the endocannabinoid system, which is also very important for fetal development," Woodbury said.

Opioids or other analgesics often don’t work against it but one treatment that has shown some promise is ketamine, an anesthetic administered through infusions that can have psychedelic properties.

When the team tested the effects of boosting acetylcholine in mice that had tolerance to opioids, they saw the same long-lasting analgesic effects.

As for pain relief, two studies were conducted to examine the analgesic effect of nostalgia on different levels of pain.