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Definitions

substance

[suhb-stuhns] / ˈsʌb stəns /
NOUN
entity, element
Synonyms
STRONGEST
item material object stuff texture
STRONG
actuality animal being body bulk concreteness core corpus fabric force hunk individual mass matter person phenomenon reality staple thing
WEAK
something
Antonyms
STRONG
abstract fantasy inanimate nothing nothingness plant
WEAK
poverty
NOUN
essence, meaning
Synonyms
STRONGEST
amount effect meat significance strength stuff subject
STRONG
ABCs basis body bottom burden center core corpus crux drift essentiality focus gist guts heart import innards kernel marrow mass matter nitty-gritty nub pith point purport quintessence sense soul staple tenor theme thrust upshot
WEAK
bottom line brass tacks general meaning gravamen name of the game nuts and bolts sum total virtuality way of it
Antonyms
STRONG
cowardice exterior exteriority fear insignificance nothing nothingness outside periphery surface
WEAK
poverty
NOUN
wealth
Synonyms
STRONG
affluence assets estate fortune means property resources riches worth
Antonyms
STRONG
debt
WEAK
poverty

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

FDA regulations also require the agency to assess both safety and effectiveness before approving a substance for compounding.

From Salon • Apr. 4, 2026

Profits will rise faster than the price of the substance, often sending shares upward faster than oil futures.

From Barron's • Apr. 3, 2026

But new early research suggests that some of these garments may contain a dangerous substance: lead.

From Science Daily • Apr. 2, 2026

In his statement, Mills does not address the substance of the allegations, provide any further detail about them or offer a denial.

From BBC • Apr. 1, 2026

I think I’m radiating awkwardness—like it’s some sort of gaseous substance, rolling off me in waves.

From "Leah on the Offbeat" by Becky Albertalli

From Roget's 21st Century Thesaurus, Third Edition Copyright © 2013 by the Philip Lief Group.