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Definitions

refractory

[ri-frak-tuh-ree] / rɪˈfræk tə ri /


ADJECTIVE
inflexible
Synonyms
Antonyms


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

RP1 is intended to help these refractory patients by boosting their response to other therapies.

From The Wall Street Journal • Apr. 14, 2026

The Food and Drug Administration has accepted a biologics license application for anito-cel as a fourth-line treatment for patients with relapsed or refractory multiple myeloma.

From Barron's • Feb. 23, 2026

"The prospect of changing the alloy and including other refractory metals to enhance the composite for nuclear applications is particularly exciting."

From Science Daily • Dec. 15, 2023

He said the medical cause of Benn's death was "refractory cardiogenic shock due to taxane alkaloid poisoning, following ingestion of yew tree berries and leaves".

From BBC • Dec. 4, 2023

So Meg wrestled alone with the refractory sweetmeats all that hot summer day, and at five o’clock sat down in her topsy-turvey kitchen, wrung her bedaubed hands, lifted up her voice and wept.

From "Little Women" by Louisa May Alcott




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