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refractory

[ri-frak-tuh-ree] / rɪˈfræk tə ri /


ADJECTIVE
inflexible
Synonyms
Antonyms


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Late-phase data for the U.K. drugmaker’s camlipixant and bepirovirsen in refractory chronic cough and hepatitis B, respectively, are due and the outcome of a portfolio review should come alongside second-quarter results, the analysts say.

From The Wall Street Journal • May 5, 2026

The Food and Drug Administration has accepted a biologics license application for anito-cel as a fourth-line treatment for patients with relapsed or refractory multiple myeloma.

From Barron's • Feb. 23, 2026

This refractory metal-based material, in whose discovery Dr. Alexander Kauffmann, now professor at the Ruhr University Bochum, played a major role, exhibits properties never seen before.

From Science Daily • Oct. 23, 2025

He said the medical cause of Benn's death was "refractory cardiogenic shock due to taxane alkaloid poisoning, following ingestion of yew tree berries and leaves".

From BBC • Dec. 4, 2023

So Meg wrestled alone with the refractory sweetmeats all that hot summer day, and at five o’clock sat down in her topsy-turvey kitchen, wrung her bedaubed hands, lifted up her voice and wept.

From "Little Women" by Louisa May Alcott




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