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Definitions

refractory

[ri-frak-tuh-ree] / rɪˈfræk tə ri /


ADJECTIVE
inflexible
Synonyms
Antonyms


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

The Food and Drug Administration has accepted a biologics license application for anito-cel as a fourth-line treatment for patients with relapsed or refractory multiple myeloma.

From Barron's • Feb. 23, 2026

Food and Drug Administration is reviewing Arcellx’s application seeking approval of anito-cel as a fourth-line treatment for patients with relapsed or refractory multiple myeloma, with a decision expected by the end of the year.

From The Wall Street Journal • Feb. 23, 2026

"Creating a refractory metal composite with these features of well-controlled hydrogen handling combined with erosion resistance and general material resilience is a breakthrough for the design of plasma devices and fusion energy systems," Schmitz says.

From Science Daily • Dec. 15, 2023

He said the medical cause of Benn's death was "refractory cardiogenic shock due to taxane alkaloid poisoning, following ingestion of yew tree berries and leaves".

From BBC • Dec. 4, 2023

So Meg wrestled alone with the refractory sweetmeats all that hot summer day, and at five o’clock sat down in her topsy-turvey kitchen, wrung her bedaubed hands, lifted up her voice and wept.

From "Little Women" by Louisa May Alcott