Thesaurus.com
Dictionary.com
Showing results for difficile. Search instead for piffigare.
Definitions

difficile

[dif-i-seel, dee-fee-seel] / ˌdɪf ɪˈsil, di fiˈsil /
ADJECTIVE
difficult
Synonyms
STRONGEST
ambitious arduous burdensome challenging crucial demanding laborious onerous painful problematic severe strenuous tough troublesome
WEAK
backbreaker bothersome easier said than done effortful exacting formidable galling gargantuan hard-won heavy herculean immense intricate irritating labored no picnic not easy operose problem prohibitive rigid stiff titanic toilsome trying unyielding uphill upstream wearisome
Antonyms
STRONGEST
easy effortless facile helpful nice trivial
WEAK
calm free friendly manageable plain simple sociable straightforward uncomplicated
ADJECTIVE
hard
Synonyms
STRONGEST
arduous complicated heavy rough serious terrible tough troublesome
WEAK
backbreaking bothersome burdensome demanding distressing effortful exacting fatiguing formidable grinding hairy herculean intricate involved irksome knotty labored laborious mean merciless murder onerous operose rigorous rugged scabrous severe slavish sticky strenuous tiring toilful toilsome unsparing uphill uphill battle wearing wearisome wearying
Antonyms
STRONGEST
easy facile
WEAK
flexible simple

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Scientists in Leiden have developed a new antibiotic called EVG7 that can combat the dangerous gut bacterium C. difficile using only a very small dose.

From Science Daily • Mar. 11, 2026

Mons and her colleagues studied how EVG7 affects C. difficile infections in mice.

From Science Daily • Mar. 11, 2026

But scientists noticed hints that faecal transplants for C. difficile also seemed to get rid of superbugs.

From BBC • Jun. 7, 2025

Faecal transplants – also known as a trans-poo-tion - are already approved for treating severe diarrhoea caused by Clostridium difficile bacteria.

From BBC • Jun. 7, 2025

Within months, outbreaks of antibiotic-resistant Pseudomonas aeruginosa, Clostridium difficile, and E. coli are observed in patients around the world.

From "We Are the Ants" by Shaun David Hutchinson