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Definitions

de novo

[dee noh-voh, dey, dih, de noh-woh] / di ˈnoʊ voʊ, deɪ, dɪ, dɛ ˈnoʊ woʊ /
ADJECTIVE
afresh
Synonyms
STRONGEST
anew once more
WEAK
again lately newly of late once again over over again recently
ADVERB
anew
Synonyms
STRONGEST
afresh once again once more recently
WEAK
another time come again from scratch from the beginning in a different way in a new way lately new newly one more time over over again

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Novel material science also includes de novo chemical combinations for batteries that can store more energy with faster charge cycles and lighter weight.

From The Wall Street Journal • Feb. 16, 2026

World Liberty Trust filed its de novo application Wednesday with the U.S.

From The Wall Street Journal • Jan. 7, 2026

And to facilitate seed sorting post-harvest, de novo crops could be created to have a different seed color or shape.

From Science Daily • Apr. 17, 2024

“Currently … it goes through a de novo review before an administrative law judge, which means a new body of records is created,” she explains.

From Science Magazine • Nov. 28, 2023

The mitochondria do not arise de novo in cells; they are always there, replicating on their own, independently of the replication of the cell.

From "The Lives of a Cell" by Lewis Thomas