irreversible

This approach provides you with flexibility to evaluate your circumstances every year, and also “avoids making a large, irreversible tax decision based on a single year’s circumstances.”

From MarketWatch ● Sep. 2, 2026

The surgery would be irreversible and would mean, for example, that Jewell would not be able to breastfeed in future.

From BBC ● Sep. 1, 2026

Instead, chromosome changes tend to move along a restricted set of irreversible pathways that the researchers describe as "evolutionary highways."

From Science Daily ● Aug. 25, 2026

Because action enters a web of other lives, its consequences are unpredictable and irreversible.

From The Wall Street Journal ● Aug. 7, 2026

He had plenty of experience of change, sometimes for better and sometimes for worse, but he had no notion of irreversible change, and he had no notion of progress.

From "The Invention of Science" by David Wootton