irreversible

They include having a "serious and incurable illness", making a "voluntary request that is not the result of external pressure" and be in an "advanced state of irreversible decline in capability".

Despite his fears, the former ambassador does not believe Israel's diplomatic isolation is irreversible.

Indeed, to most Americans in the leftward and more metropolitan half of the population, all of this looked like a process of irreversible and irresistible change.

The loss of institutional memory through departing senior technicians and researchers creates irreversible damage to laboratory operations and research continuity.

“You all support off-label, untested, and irreversible hormonal ‘therapies’ for children,” he wrote.