difficile

[dif-i-seel, dee-fee-seel] / ˌdɪf ɪˈsil, di fiˈsil /

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difficult adj.
hard adj.

ADJECTIVE

difficult

Synonyms

STRONGEST

ambitious arduous burdensome challenging crucial demanding laborious onerous painful problematic severe strenuous tough troublesome

WEAK

backbreaker bothersome easier said than done effortful exacting formidable galling gargantuan hard-won heavy herculean immense intricate irritating labored no picnic not easy operose problem prohibitive rigid stiff titanic toilsome trying unyielding uphill upstream wearisome

Antonyms

STRONGEST

easy effortless facile helpful nice trivial

WEAK

calm free friendly manageable plain simple sociable straightforward uncomplicated

ADJECTIVE

hard

Synonyms

STRONGEST

arduous complicated heavy rough serious terrible tough troublesome

WEAK

backbreaking bothersome burdensome demanding distressing effortful exacting fatiguing formidable grinding hairy herculean intricate involved irksome knotty labored laborious mean merciless murder onerous operose rigorous rugged scabrous severe slavish sticky strenuous tiring toilful toilsome unsparing uphill uphill battle wearing wearisome wearying

Antonyms

STRONGEST

easy facile

WEAK

flexible simple

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

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difficile

Scientists in Leiden have developed a new antibiotic called EVG7 that can combat the dangerous gut bacterium C. difficile using only a very small dose.

From Science Daily ● Mar. 11, 2026

The paper 'Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family' was published in Nature Communications.

From Science Daily ● Mar. 11, 2026

Mons and her colleagues studied how EVG7 affects C. difficile infections in mice.

From Science Daily ● Mar. 11, 2026

Faecal transplants – also known as a trans-poo-tion - are already approved for treating severe diarrhoea caused by Clostridium difficile bacteria.

From BBC ● Jun. 7, 2025

Excessive abdominal noise is an uncommon, but not unprecedented, presenting symptom of infection with the bacteria Clostridium difficile, which can be fatal.

From "Turtles All the Way Down" by John Green

difficile

Example Sentences

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