genetic

Using genetic engineering tools and modified viruses, the scientists precisely corrected the dysfunction in the basolateral amygdala and tracked changes in both neuronal activity and overall behavior.

"This validates our findings and gives us confidence that the mechanism we identified is not exclusive to a specific genetic model, but may represent a general principle for how these emotions are regulated in the brain," Lerma notes.

A deeper look at blood biomarkers and genetic data revealed more than simple associations -- it pointed to biological mechanisms that may drive these changes.

This analysis revealed a genetic signature made up of 53 genes that consistently distinguished between aggressive, inflammatory macrophages and those responsible for repairing tissue.

The findings explain how a crucial genetic mutation drives inflammation and could guide the development of new therapies aimed at restoring the lost partnership between girdin and NOD2.