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Definitions

predisposition

[pree-dis-puh-zish-uhn, pree-dis-] / priˌdɪs pəˈzɪʃ ən, ˌpri dɪs- /
NOUN
willingness, inclination
Synonyms
STRONGEST
disposition predilection proclivity propensity susceptibility
STRONG
bent bias choice dish druthers flash groove leaning likelihood liking option partiality penchant potentiality preference proneness tendency thing type weakness
WEAK
cup of tea
Antonyms
STRONGEST
antipathy disinclination dislike hate
STRONG
fairness hatred impartiality
WEAK
unwillingness

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Your ideal rise time is linked to your chronotype, your genetic predisposition to waking at a certain time.

From The Wall Street Journal • Jan. 11, 2026

The Oscar-winning actor announced in 2013 that she had undergone a double mastectomy, followed by a double oophorectomy in 2015, due to her genetic predisposition to cancer.

From Barron's • Dec. 15, 2025

Genetic predisposition increases disease risk in certain populations.

From Science Daily • Nov. 17, 2025

It can be useful to detect an individual's predisposition to conditions like heart disease and common cancers.

From BBC • Nov. 14, 2025

For a while she’d struggled against her predisposition.

From "Middlesex: A Novel" by Jeffrey Eugenides

From Roget's 21st Century Thesaurus, Third Edition Copyright © 2013 by the Philip Lief Group.