excitability

The discovery, published in iScience, shows that restoring the balance of neuronal excitability within a precise part of the amygdala can reverse these behavioral changes in mice.

"While it's often overlooked, aperiodic activity is important because it reflects brain cortical excitability," said study senior author Christopher T. Whitlow, M.D.,

With this pacing protocol, the team was able to effectively control and terminate cardiac arrhythmias even at low energy intensities that do not activate the heart, but only modulate its excitability.

There is increasing evidence that psychiatric diseases such as schizophrenia and bipolar disorder stem from metabolic deficits in the brain, which affect the excitability of neurons, Sethi said.

It may be used to treat conditions such as depression, where altered brain excitability and plasticity are prominent features.