centriole

This work, published in the journal Cell, elucidates the complexities of centriole assembly.

All eukaryotes have the exact same set of organelles familiar to anyone who has studied cell biology: nucleus, nucleolus, ribosomes, rough and smooth endoplasmic reticulum, Golgi apparatus, cytoskeleton, lysosome and centriole.

Until a few years ago, it was impossible to visualise the structure of the centriole in detail.

This unique approach, which combines the very high resolution of expansion microscopy and kinematic reconstruction, has enabled us to model the first 4D assembly of the human centriole.

Obtaining images of the centriole with such high resolution enables the exact location of proteins at a given time but gives no information on the order of appearance of substructural domains or of individual proteins.