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Definitions

antagonist

[an-tag-uh-nist] / ænˈtæg ə nɪst /


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Neurocrine already markets Crenessity, an oral CRF1 receptor antagonist used to treat congenital adrenal hyperplasia, which is a collection of genetic disorders affecting the adrenal glands.

From MarketWatch • Apr. 6, 2026

Veteran video game actor Troy Baker is nominated twice - for his lead performance as Indiana Jones in The Great Circle and for his supporting role as antagonist Higgs in Death Stranding 2.

From BBC • Mar. 12, 2026

Leavitt also leaned into her favorite antagonist — the press.

From Salon • Mar. 6, 2026

The Prime Video series premiering Wednesday reimagines the fictional detective’s early years as he investigates a murder case that originates at Oxford, where he first meets his eventual antagonist.

From Los Angeles Times • Mar. 4, 2026

Franklin regarded nature as an antagonist that would inevitably submit to force, good breeding, and Victorian discipline.

From "Into the Wild" by Jon Krakauer