| Main Entry: | |
| Part of Speech: | noun |
| Definition: | severe upset or pain |
| Synonyms: | affliction, agony, distress, dole, dolor, grief, heartache, heartbreak, hurting, misery, pang, rue, sorrow, suffering, throe, torment, torture, woe, wretchedness |
| Antonyms: | comfort, contentment, happiness, joy, joyfulness, solace |
| Main Entry: | affliction |
| Part of Speech: | noun |
| Definition: | hurt condition; something that causes hurt |
| Synonyms: | adversity, anguish, calamity, cross, crux, depression, difficulty, disease, disorder, distress, grief, hardship, illness, infirmity, misery, misfortune, ordeal, pain, plague, plight, scourge, sickness, sorrow, suffering, torment, trial, tribulation, trouble, woe |
| Antonyms: | aid, comfort, consolation, health, help, relief |
| Main Entry: | agony |
| Part of Speech: | noun |
| Definition: | suffering, pain |
| Synonyms: | affliction, anguish, distress, dolor, misery, pangs, passion, throes, torment, torture, woe |
| Antonyms: | comfort, happiness, health, peace, success |
| Main Entry: | bitterness |
| Part of Speech: | noun |
| Definition: | agony |
| Synonyms: | acrimoniousness, anguish, asperity, distress, grievousness, harshness, hostility, mordancy, pain, painfulness, sarcasm, venom, virulence |
| Antonyms: | contentment, geniality, happiness, sweetness |
| Main Entry: | care |
| Part of Speech: | noun |
| Definition: | personal interest, concern |
| Synonyms: | affliction, aggravation, alarm, anguish, annoyance, anxiety, apprehension, bother, burden, chagrin, charge, consternation, discomposure, dismay, disquiet, distress, disturbance, encumbrance, exasperation, fear, foreboding, fretfulness, handicap, hardship, hindrance, impediment, incubus, load, misgiving, nuisance, onus, oppression, perplexity, pressure, responsibility, solicitude, sorrow, stew, strain, stress, sweat, tribulation, trouble, uneasiness, unhappiness, vexation, woe, worry |
| Antonyms: | carelessness, disregard, ignorance, inattention, neglect, negligence, oversight, thoughtlessness |
| Main Entry: | desolation |
| Part of Speech: | noun |
| Definition: | distress, unhappiness |
| Synonyms: | anguish, dejection, despair, gloom, gloominess, loneliness, melancholy, misery, mourning, sadness, sorrow, woe, wretchedness |
| Antonyms: | cheer, comfort, happiness, joy |
| Main Entry: | despair |
| Part of Speech: | noun |
| Definition: | depression, hopelessness |
| Synonyms: | anguish, dashed hopes, dejection, desperation, despondency, discouragement, disheartenment, forlornness, gloom, melancholy, misery, ordeal, pain, sorrow, trial, tribulation, wretchedness |
| Antonyms: | cheer, cheerfulness, confidence, faith, happiness, hopefulness, joy, joyfulness, trust |
| Main Entry: | desperation |
| Part of Speech: | noun |
| Definition: | hopelessness |
| Synonyms: | agony, anguish, anxiety, concern, dejection, depression, desolation, despair, despondency, discomfort, disconsolateness, distraction, distress, fear, gloom, grief, heartache, melancholy, misery, pain, pang, sorrow, torture, trouble, unhappiness, worry |
| Antonyms: | confidence, contentment, security |
| Main Entry: | distress |
| Part of Speech: | noun |
| Definition: | pain, agony |
| Synonyms: | ache, affliction, anguish, anxiety, bad news, blues, care, concern, cross, dejection, desolation, disappointment, discomfort, disquietude, dolor, embarrassment, grief, headache, heartache, heartbreak, irritation, malaise, misery, mortification, ordeal, pang, perplexity, sadness, shame, sorrow, stew, suffering, throe, torment, torture, trial, tribulation, trouble, twinge, unconsolability, unhappiness, vexation, visitation, woe, worriment, worry, wretchedness |
| Antonyms: | comfort, happiness, health, pleasure |