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Adjectives:

a prey to, a prey to grief, abhorrent, accursed, aching, acute, affecting, afflicted, afflicting, afflictive, aggravating, agonizing, algedonic, amyctic, annoying, anxious, aponic, appalling, awkward, between hawk and buzzard, biting, bitter, bothering, broken, calamitous, careworn, carking, causing pain, caustic, chagrined, cheerless, comfortless, concerned, consuming, corroding, cruel, crushed, crushing, cumbersome, cumbrous, cut up, cutting, deplorable, depressing, depressive, desolating, devoted, dire, disagreeable, disastrous, discontented, disgusting, disheartening, dismal, displeased, displeasing, distasteful, distressing, disturbed, dolorific, dolorous, doomed, dreadful, dreary, enough to drive one mad, enough to make a person swear, enough to provoke a saint, envenomed, excruciating, execrable, fashed, fearful, frightful, full of pain, fulsome, galling, grating, grave, grievous, grim, grinding, griped, hagridden, harassing, hard, harrowing, harsh, hateful, heart, heart, heart, heart, heavy, horrible, horrid, horrific, horrified, horrifying, horror, hurting, ill, ill at ease, in a state of pain, in a taking, in a way, in despair, in grief, in limbo, in pain, in tears, infelicitous, insufferable, insupportable, intolerable, invidious, irksome, irritating, joyless, kedogenous, lamentable, loathful, loathsome, lost, melancholy, melpomenish, miserable, more than flesh and blood can bear, mortifying, mournful, nasty, nauseating, nauseous, not to be borne, not to be endured, obnoxious, odious, offensive, on the rack, onerous, oppressive, out of humor, pained, painful, past bearing, pathetic, pestering, piteous, pitiable, plaguing, plaguy, plunged in grief, poor, provoking, racking, rending, repellent, repulsive, revolting, rueful, ruinous, sad, searching, severe, sharp, shocking, sickening, sore, sorrowful, sorrowing, sorry, steeped to the lips in misery, stinging, stranded, stricken, suffering, teasing, terrific, thankless, thrilling, tiresome, to be pitied, tormenting, torminous, torturous, touching, tragical, tremendous, troublesome, unacceptable, unaccommodating, unbearable, uncomfortable, undesirable, undesired, undone, uneasy, unendurable, unfortunate, unhappy, uninviting, unlucky, unpalatable, unpleasant, unpleasing, unpopular, unsatisfactory, untoward, unwelcome, vexatious, victimized, vile, vulnerative, wearisome, weary, withering, wobegone, woeful, worried, worrying, wretched